摘要

2019-11-06 17:04:32
ADC秘书处
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最后编辑:ADC秘书处 于 2019-11-06 17:22:24
田金洲 1 解恒革 2 秦斌 3 樊东升 4 卢涛 5 时晶 1 倪敬年 1 王鲁宁 2 王荫华 6
代表中国老年保健协会 阿尔茨海默病分会研究小组
1 北京中医药大学东直门医院脑病科100700; 2 解放军总医院南楼神经科,北京100853; 3北京医院神经内科100730; 4 北京大学第三医院神经内科100191; 5北京中医药大学生命科学学院100029; 6 北京大学第一医院神经内科100034
通信作者:田金洲,Email:jztian@hotmail.com

【提要】针对我国认知筛查标准化体系缺乏和脑血管病影像学特征认定存在争议等问题,该研究小组利用神经心理学、神经影像学和临床神经病学等知识和技术,对血管性 痴呆诊断涉及的记忆、语言、视空间、执行、功能和MRI脑血管病证据等检测技术及其最佳阈值和诊断价值进行了系统研究,并通过系统综述和共识会议等形式,将原则性的诊断指南与操作性的筛查方案相结合,构建了适用于中国人群的血管性痴呆筛查和诊断框架。该框架以病史和临床评估的客观证据为核心特征,以与临床一致的脑血管病影像学证据为支持特征,并排除痴呆的其他 病因或伴随病变,适用于我国临床环境,对血管性痴呆的早发现、早诊断、早治疗具有重要意义。

【关键词】痴呆,血管性; 筛查和诊断; 框架

基金项目:中国工程院咨询研究项目(2017-ZD-06);教育部/国家外国专家局高等学校学科创新引智计划(B08006);教育部长江学者和创新团队发展计划(阿尔茨海默病)(IRT0810)

DOI:10.3760/cma.j.issn.0578-1426.2019.01.003

Screening and diagnostic framework of vascular dementia in Chinese population

Tian Jinzhou 1, Xie Hengge 2, Qin Bin 3, Fan Dongsheng 4, Lu Tao 5, Shi Jing 1, Ni Jingnian 1, Wang Luning 2, Wang Yinhua 6
The Research Group of Alzheimer′s Disease Chinese
1Neurology Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China; 2Department of Geriatric Neurology,Chinese PLA General Hospital, Beijing 100853,China; 3Department of Neurology, Beijing Hospital, Beijing 100730, China; 4Department of Neurology, Peking
University Third Hospital, Beijing 100191, China; 5School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China; 6Department of Neurology, Peking University First Hospital, Beijing 100034, China
Corresponding author: Tian Jinzhou, Email: jztian@hotmail.com

【Summary】For lack of cognitive screening standard system and controversy over the value of imaging for cerebrovascular diseases in China, the research group of Alzheimer′s Disease Chinese ( ADC) studied the knowledge of neuropsychology, neuroimaging and clinical neurology, systematically reviewed the diagnostic techniques such as memory, language, visuospatial, executive, function, and magnetic resonance imaging (MRI) of cerebrovascular diseases, and their optimal threshold and diagnostic value for vascular dementia. Via a consensus meeting, the diagnostic guidelines and practical screening process are combined to construct a framework in Chinese population, which is based on the objective evidence of medical history and clinical evaluation. The diagnosis of vascular dementia is supported by imaging evidence of cerebrovascular diseases and differentiates from other causes of dementia or comorbidities. This consensus is applicable to medical units in China, and is of great significance for early detection, early diagnosis and early treatment of vascular dementia.

【Key words】Dementia, vascular; Screening and diagnostic; Framework

Fund programs: China Academy of Engineering′s Consulting Research Project (2017-ZD-06); Ministry of Education/National Foreign Experts Bureau′s Higher Education Discipline Innovation Initiative (B08006); Minister of Education′s Cheung Kung Scholar and Innovation Team Development Programme (Alzheimer′s Disease) (IRT0810)

DOI:10.3760/cma.j.issn.0578-1426.2019.01.003

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