摘要

2019-11-06 17:04:32
ADC秘書處
364
最後編輯:admin 於 2019-11-06 17:22:24
田金洲 1 解恆革 2 秦斌 3 樊東陞 4 盧濤 5 時晶 1 倪敬年 1 王魯寧 2 王蔭華 6
代錶中國老年保健協會 阿爾茨海默病分會研究小組
1 北京中醫藥大學東直門醫院腦病科100700; 2 解放軍總醫院南樓神經科,北京100853; 3北京醫院神經內科100730; 4 北京大學第三醫院神經內科100191; 5北京中醫藥大學生命科學學院100029; 6 北京大學第一醫院神經內科100034
通信作者:田金洲,Email:jztian@hotmail.com

【提要】針對我國認知篩查標準化體繫缺乏和腦血管病影像學特徵認定存在爭議等問題,該研究小組利用神經心理學、神經影像學和臨床神經病學等知識和技術,對血管性 癡獃診斷涉及的記憶、語言、視空間、執行、功能和MRI腦血管病證據等檢測技術及其最佳閾值和診斷價值進行瞭繫統研究,併通過繫統綜述和共識會議等形式,將原則性的診斷指南與操作性的篩查方案相結閤,構建瞭適用於中國人群的血管性癡獃篩查和診斷框架。該框架以病史和臨床評估的客觀證據爲核心特徵,以與臨床一緻的腦血管病影像學證據爲支持特徵,併排除癡獃的其他 病因或伴隨病變,適用於我國臨床環境,對血管性癡獃的早髮現、早診斷、早治療具有重要意義。

【關鍵詞】癡獃,血管性; 篩查和診斷; 框架

基金項目:中國工程院諮詢研究項目(2017-ZD-06);教育部/國傢外國專傢局高等學校學科創新引智計劃(B08006);教育部長江學者和創新糰隊髮展計劃(阿爾茨海默病)(IRT0810)

DOI:10.3760/cma.j.issn.0578-1426.2019.01.003

Screening and diagnostic framework of vascular dementia in Chinese population

Tian Jinzhou 1, Xie Hengge 2, Qin Bin 3, Fan Dongsheng 4, Lu Tao 5, Shi Jing 1, Ni Jingnian 1, Wang Luning 2, Wang Yinhua 6
The Research Group of Alzheimer′s Disease Chinese
1Neurology Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China; 2Department of Geriatric Neurology,Chinese PLA General Hospital, Beijing 100853,China; 3Department of Neurology, Beijing Hospital, Beijing 100730, China; 4Department of Neurology, Peking
University Third Hospital, Beijing 100191, China; 5School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China; 6Department of Neurology, Peking University First Hospital, Beijing 100034, China
Corresponding author: Tian Jinzhou, Email: jztian@hotmail.com

【Summary】For lack of cognitive screening standard system and controversy over the value of imaging for cerebrovascular diseases in China, the research group of Alzheimer′s Disease Chinese ( ADC) studied the knowledge of neuropsychology, neuroimaging and clinical neurology, systematically reviewed the diagnostic techniques such as memory, language, visuospatial, executive, function, and magnetic resonance imaging (MRI) of cerebrovascular diseases, and their optimal threshold and diagnostic value for vascular dementia. Via a consensus meeting, the diagnostic guidelines and practical screening process are combined to construct a framework in Chinese population, which is based on the objective evidence of medical history and clinical evaluation. The diagnosis of vascular dementia is supported by imaging evidence of cerebrovascular diseases and differentiates from other causes of dementia or comorbidities. This consensus is applicable to medical units in China, and is of great significance for early detection, early diagnosis and early treatment of vascular dementia.

【Key words】Dementia, vascular; Screening and diagnostic; Framework

Fund programs: China Academy of Engineering′s Consulting Research Project (2017-ZD-06); Ministry of Education/National Foreign Experts Bureau′s Higher Education Discipline Innovation Initiative (B08006); Minister of Education′s Cheung Kung Scholar and Innovation Team Development Programme (Alzheimer′s Disease) (IRT0810)

DOI:10.3760/cma.j.issn.0578-1426.2019.01.003

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